A wonderful new mod called Skyrim Priority - SKSE. It changes CPU usage to High, preventing background programs from interfering with Skyrim SE. "It ensure [s] the game always take [s].
Go inside skyrim and load your save game ( The CTD one) then Disabled Save on Wait, Save on Sleep, Save on Travel, Save on Character Menu in Settings > Gameplay. Pretty much disabled.
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Mod List: UPDATED ONE IN COMMENTS 0 0 Skyrim.esm 1 1 Update.esm 2 2 Dawnguard.esm 3 3 HearthFires.esm 4 4 Dragonborn.esm 5 5 Unofficial Skyrim Special Edition Patch.esp 6 6 Lanterns Of Skyrim - All In One - Main.esm 7 7 SkyUI_SE.esp 8 8 Obsidian Weathers.esp 9 9 SMIM-SE-Merged-All.esp 10 a FNIS.esp.
Solved once with a full Skyrim reinstallation but later the problem came back. And after a few iterations i found the reason, it was Vortex and one of my mods. This mod had no metainfo for a mod manager and contained a lot of nested optional directories with too long names. This is old mod and it was probably meant to be installed manually only.
The Skyrim is a 32-bit game while the special edition is a 64-bit game. The Skyrim special edition is more stable than the original edition. In addition, if you use the original edition, once the RAM usage of the game exceeds 3.1GB, Skyrim CTD will happen. The Skyrim original edition has more MODs, because it was released earlier.
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